⚜ It Helps Shed Dead Skin & cleanses the skin's pores
⚜ Lightens Scars
⚜ Improves complexion and provides spectacular Glow.
⚜ Strengthens the skin barrier
⚜ Effortlessly removes tan while preserving the skin's natural radiance and vitality
⚜ Slows down the skin’s aging process and boosts the growth of new skin cells
⚜ Prevents aging signs such as wrinkles, age spots and fine lines
⚜ Gives the skin a supple, soft and fresh texture
⚜ Tightens the facial skin
⚜ Helps treat skin discolouration
⚜ Lightens skin Tone and banishes dullness
⚜ Protects from the effects of ultraviolet rays, pollution, infections and stress
⚜ Contains moisturizing and nourishing effects
⚜ Makes the skin smooth and provides flawless texture
⚜ Reduces the appearance of dark spots, evens out the skin tone, and hydrates the skin
⚜ Extremely light and non-greasy formulation that helps the skin heal from the damage caused by exposure to the sun.
⚜ Enhances the elasticity of the skin & balances the skin pH levels.
⚜ Possesses active ingredients that get easily absorbed into the skin
⚜ Boosts collagen & keep the skin youthful
⚜ Possesses anti-wrinkle powers.
⚜ Provides skin moisturizing effects as it increases skin moisture content.
⚜ Soothes damaged skin

BASIL + TEA TREE + SWEET-LIME

⚜ Cleanse face with a cleanser. Pat dry
⚜ Gently pour 3-5 drops of this oil on the face and neck area
⚜ Gently massage it in the skin in a circular motion, till its completely absorbed

Before going to bed at night.

⚪ All skin types. For women and men.
⚪ Recommended for those seeking a solution for:
⚜ Tan & Sun damage
⚜ Dull skin
⚜ Uneven skin tone
⚜ Dryness

BestIndian™ practices 100% transparency, and believes in disclosing all ingredients used in its products. BestIndian™ guarantees that no other ingredient, apart from those listed below, has been used in this 100% natural and synthetic chemicals free BestIndian Luxury:

⚪ Jojoba Oil ⚪ Kalonji Oil ⚪ Essential Oils Of Sweet Basil, Rosemary, Eucalyptus, Tea tree & Sweet lime.

⚜ Store in a cool and dry place, away from direct sunlight.
⚜ For external use only.
⚜ Reading the ingredients list is recommended to ensure that the user is not allergic to any ingredient herb.
⚜ Patch test is recommended on a small area of the skin prior to first usage.

This product has been thoroughly tested by dermatologists and is guaranteed safe and dermatologist approved.

Bharat

⚪ Mechanism of de-tanning action

De-tanning works by reducing the presence of melanin pigment in the skin. To accomplish this, there are several possible mechanisms of action:
• Inhibition of the activity of tyrosinase: The catalytic action of tyrosinase is inhibited by the de-tanning agent.
• Inhibition of the expression or activation of tyrosinase: The anti melanogenic agent causes less tyrosinase to be generated or prevents tyrosinase from being activated to its functional form.
• Scavenging of the intermediate products of melanin synthesis.
• Preventing the transfer of melanosomes to keratinocytes

⚪ Inhibition of tyrosinase:
Upregulation of tyrosinase caused by tyrosinase inhibitors. Several de-tanning agents, including tyrosinase inhibitors, have been found to cause an increase in the expression of tyrosinase, which by itself would increase melanin synthesis.
Microphthalmia-associated transcription factor (MITF) is the master transcription factor that controls the expression of TYR, TRP1, and TRP2, MART1, PMEL17, and many other important proteins involved in the function of melanocytes. Downregulation of MITF decreases melanogenesis and is a mechanism of action of some de-tanning agents. Various signaling pathways and genetic mutations influence the expression of MITF.
⚪ MC1R receptor and cAMP
The melanocortin 1 receptor (MC1R) is a transmembrane and G-protein coupled receptor expressed in melanocytes. MC1R is an important target for the regulation of melanogenesis. Agonism of MC1R increases the ratio of eumelanin to pheomelanin and increases the generation of melanin overall.
The MC1R and cAMP signaling pathway starts with the activation of MC1R, which causes activation of adenylyl cyclase (AC), which produces cyclic adenosine monophosphate (cAMP), which activates protein kinase A (PKA), which activates by protein phosphorylation cAMP response element-binding protein (CREB), which upregulates MITF, of which CREB is a transcription factor.
Alpha-melanocyte stimulating hormone (α-MSH), beta-melanocyte stimulating hormone (β-MSH), and adrenocorticotropic hormone are endogenous agonists of MC1R.[44]: 1175  Agouti signaling protein (ASIP) appears to be the only endogenous antagonist of MC1R. Synthetic MC1R agonists have been designed, such as the peptides afamelanotide and melanotan II.
⚪ Transfer of melanosomes
Within the skin, melanocytes are present in the basal layer of the epidermis; from these, melanocytes originate dendrites that reach keratinocytes.
Melanosomes, along with the melanin they contain, are transferred from melanocytes to keratinocytes when keratinocytes are low in the epidermis. Keratinocytes carry the melanosomes with them as they move toward the surface. Keratinocytes contribute to skin pigmentation by holding the melanin originating in melanocytes and inducing melanogenesis through chemical signals directed at melanocytes. The transfer of melanosomes to keratinocytes is a necessary condition for the visible pigmentation of the skin. Blocking this transfer is a mechanism of action of some de-tanning agents.
The protease-activated receptor 2 (PAR2) is a transmembrane and G-protein coupled receptor expressed in keratinocytes and involved in melanocyte transfer. Antagonists of PAR2 inhibit the transfer of melanosomes and have de-tanning effects, while agonists of PAR2 have the opposite effect.

⚜ It Helps Shed Dead Skin & cleanses the skin's pores
⚜ Lightens Scars
⚜ Improves complexion and provides spectacular Glow.
⚜ Strengthens the skin barrier
⚜ Effortlessly removes tan while preserving the skin's natural radiance and vitality
⚜ Slows down the skin’s aging process and boosts the growth of new skin cells
⚜ Prevents aging signs such as wrinkles, age spots and fine lines
⚜ Gives the skin a supple, soft and fresh texture
⚜ Tightens the facial skin
⚜ Helps treat skin discolouration
⚜ Lightens skin Tone and banishes dullness
⚜ Protects from the effects of ultraviolet rays, pollution, infections and stress
⚜ Contains moisturizing and nourishing effects
⚜ Makes the skin smooth and provides flawless texture
⚜ Reduces the appearance of dark spots, evens out the skin tone, and hydrates the skin
⚜ Extremely light and non-greasy formulation that helps the skin heal from the damage caused by exposure to the sun.
⚜ Enhances the elasticity of the skin & balances the skin pH levels.
⚜ Possesses active ingredients that get easily absorbed into the skin
⚜ Boosts collagen & keep the skin youthful
⚜ Possesses anti-wrinkle powers.
⚜ Provides skin moisturizing effects as it increases skin moisture content.
⚜ Soothes damaged skin

BASIL + TEA TREE + SWEET-LIME

⚜ Cleanse face with a cleanser. Pat dry
⚜ Gently pour 3-5 drops of this oil on the face and neck area
⚜ Gently massage it in the skin in a circular motion, till its completely absorbed

Before going to bed at night.

⚪ All skin types. For women and men.
⚪ Recommended for those seeking a solution for:
⚜ Tan & Sun damage
⚜ Dull skin
⚜ Uneven skin tone
⚜ Dryness

BestIndian™ practices 100% transparency, and believes in disclosing all ingredients used in its products. BestIndian™ guarantees that no other ingredient, apart from those listed below, has been used in this 100% natural and synthetic chemicals free BestIndian Luxury:

⚪ Jojoba Oil ⚪ Kalonji Oil ⚪ Essential Oils Of Sweet Basil, Rosemary, Eucalyptus, Tea tree & Sweet lime.

⚜ Store in a cool and dry place, away from direct sunlight.
⚜ For external use only.
⚜ Reading the ingredients list is recommended to ensure that the user is not allergic to any ingredient herb.
⚜ Patch test is recommended on a small area of the skin prior to first usage.

This product has been thoroughly tested by dermatologists and is guaranteed safe and dermatologist approved.

Bharat

⚪ Mechanism of de-tanning action

De-tanning works by reducing the presence of melanin pigment in the skin. To accomplish this, there are several possible mechanisms of action:
• Inhibition of the activity of tyrosinase: The catalytic action of tyrosinase is inhibited by the de-tanning agent.
• Inhibition of the expression or activation of tyrosinase: The anti melanogenic agent causes less tyrosinase to be generated or prevents tyrosinase from being activated to its functional form.
• Scavenging of the intermediate products of melanin synthesis.
• Preventing the transfer of melanosomes to keratinocytes

⚪ Inhibition of tyrosinase:
Upregulation of tyrosinase caused by tyrosinase inhibitors. Several de-tanning agents, including tyrosinase inhibitors, have been found to cause an increase in the expression of tyrosinase, which by itself would increase melanin synthesis.
Microphthalmia-associated transcription factor (MITF) is the master transcription factor that controls the expression of TYR, TRP1, and TRP2, MART1, PMEL17, and many other important proteins involved in the function of melanocytes. Downregulation of MITF decreases melanogenesis and is a mechanism of action of some de-tanning agents. Various signaling pathways and genetic mutations influence the expression of MITF.
⚪ MC1R receptor and cAMP
The melanocortin 1 receptor (MC1R) is a transmembrane and G-protein coupled receptor expressed in melanocytes. MC1R is an important target for the regulation of melanogenesis. Agonism of MC1R increases the ratio of eumelanin to pheomelanin and increases the generation of melanin overall.
The MC1R and cAMP signaling pathway starts with the activation of MC1R, which causes activation of adenylyl cyclase (AC), which produces cyclic adenosine monophosphate (cAMP), which activates protein kinase A (PKA), which activates by protein phosphorylation cAMP response element-binding protein (CREB), which upregulates MITF, of which CREB is a transcription factor.
Alpha-melanocyte stimulating hormone (α-MSH), beta-melanocyte stimulating hormone (β-MSH), and adrenocorticotropic hormone are endogenous agonists of MC1R.[44]: 1175  Agouti signaling protein (ASIP) appears to be the only endogenous antagonist of MC1R. Synthetic MC1R agonists have been designed, such as the peptides afamelanotide and melanotan II.
⚪ Transfer of melanosomes
Within the skin, melanocytes are present in the basal layer of the epidermis; from these, melanocytes originate dendrites that reach keratinocytes.
Melanosomes, along with the melanin they contain, are transferred from melanocytes to keratinocytes when keratinocytes are low in the epidermis. Keratinocytes carry the melanosomes with them as they move toward the surface. Keratinocytes contribute to skin pigmentation by holding the melanin originating in melanocytes and inducing melanogenesis through chemical signals directed at melanocytes. The transfer of melanosomes to keratinocytes is a necessary condition for the visible pigmentation of the skin. Blocking this transfer is a mechanism of action of some de-tanning agents.
The protease-activated receptor 2 (PAR2) is a transmembrane and G-protein coupled receptor expressed in keratinocytes and involved in melanocyte transfer. Antagonists of PAR2 inhibit the transfer of melanosomes and have de-tanning effects, while agonists of PAR2 have the opposite effect.